FIG. 2.

Mast cell responses and infections in anti-c-kit-treated mice. C57BL/6J mice were not infected (A) or infected (B and C) with 10⁶ G. lamblia trophozoites and treated on days 2, 4, 6, and 8 with either control IgG (B) or anti-c-kit antibody (C). On day 10 postinfection, small intestines were fixed in formalin and paraffin sections were stained for chloroacetate esterase activity (red) to visualize mast cells and counterstained with hematoxylin. Similar results were seen with 8 mice/group. (D) Parasite numbers were determined in C57BL/6J mice infected with Giardia for 10 days and untreated (diamonds), treated with anti-c-kit (triangles), or treated with control IgG (circles). Each symbol represents a single mouse (n = 8 mice/group). *, P < 0.05 compared to wild-type controls. Data are representative of the results from three independent experiments.