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. 2004 Nov;72(11):6211–6220. doi: 10.1128/IAI.72.11.6211-6220.2004

FIG. 9.

FIG. 9.

No differences in the concentrations of inflammatory cytokines were seen in BALF of Pneumocystis-infected pups born to naïve dams compared to those seen in pups born to immune dams through day 19 postinfection. Dams were given i.t. inoculations of Pneumocystis on the day of breeding and boosted with i.n. inoculums on day 16 of gestation. Control dams received inoculations of PBS. Pups in both groups were then given i.n. inoculations of P. carinii within 72 h of birth. BALF was collected from pups from immunized and naïve dams and from immunized and naïve adult mice. TNF-α, IFNγ, MCP-1, and IL-6 (panels A, B, C, and D, respectively) concentrations were determined by flow cytometry using cytometric bead arrays. Data represent the means ± SD for four to five mice per group. *, P < 0.05 compared to all other groups at the same time point, **, P < 0.05 compared to adult groups at the same time point.