FIG. 1.

(A) Illustration showing the location of immunodominant B-cell epitope and the T1 epitope within the central repeat region and the universal T* epitope in the C terminus of P. falciparum CS protein. (B) Diagram of ICC-1132 monomer showing the CS protein T1 and B repeat epitopes inserted in the loop region (light and hatched boxes) and the T* epitope inserted at the C terminus of the truncated HBc protein (dark box). HBc monomer α-helical regions are represented as cylinders, and HBc amino acid residues are shown in circles. Reprinted and modified from Nature (6) with permission of the author and publisher.