TABLE 1.
Flagellin stimulates the production of a spectrum of cytokines in the mouse lunga
| Mouse strain | Fold induction of indicated cytokine (ratio of flagelline to 229)
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| TNF-α | IL-6 | G-CSF | KC | MIP-2 | MIP-1α | IL-12p40 | IL-12p70 | Eotaxin | |
| BALB/c | 9 | 52 | 7 | 5 | 6 | 4 | 6 | 5 | 4 |
| C3H/HeN | 14 | 8 | 6 | 11 | 10 | 18 | ND | ND | ND |
| C3H/HeJ | 56 | 8 | 6 | 15 | 9 | 4 | ND | ND | ND |
| B6;129 | 1,428 | 33 | 32 | 493 | 12 | ND | ND | ND | |
| TNFR−/− | 35 | 40 | 37 | 54 | 14 | ND | ND | ND | ND |
a
BALF from groups of three to five mice were pooled for analysis by using Mouse Cytokine Array II from RayBiotech, Inc. Cytokines with a >4-fold increase in the ratio of flagellin induction to 229 induction are shown. ND, no difference.