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Immunized IL-15−/− mice are resistant to virulent T. gondii challenge. Mice were vaccinated with the avirulent ts4 parasite strain and challenged 8 months later with the virulent RH strain. Naïve mice (n = 3) succumbed to infection rapidly, whereas vaccinated mice (n = 4) were resistant to challenge. This is one representative experiment and similar data were observed 1, 2, and 6 months postvaccination. WT, wild type; KO, knockout.
