Table 2. Immunohistochemistry results (mean ± standard deviation) of Bcl-2, Bax, and Bad expression in luminal epithelial cells of canine mammary tumors.
| Bcl2 | Bax | Bad | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Positive cells % | Positive cells intensity | IRS | Allred | Positive cells % | Positive cells intensity | IRS | Allred | Positive cells % | Positive cells intensity | IRS | Allred | |
| Healthy/hyperplastic tissue | 100.00 ± 0.00 | 0.96 ± 0.31 | 3.85 ± 1.23 | 5.96 ± 0.31 | 91.43 ± 19.57 | 0.61 ± 0.21 | 2.30 ± 0.96 | 5.48 ± 0.44 | 100.00 ± 0.00 | 0.59 ± 0.24 | 2.36 ± 0.95 | 5.59 ± 0.24 |
| Benign tumors (24) | 90.50 ± 27.62 | 0.95 ± 0.43 | 3.65 ± 1.92 | 5.65 ± 1.15 | 90.50 ± 19.32 | 1.08 ± 0.47 | 3.93 ± 1.79 | 5.98 ± 0.57 | 97.50 ± 7.86 | 1.03 ± 0.47 | 4.05 ± 1.90 | 6.03 ± 0.47 |
| Malignant tumors (54) | 95.81 ± 16.65 | 1.35 ± 0.57** | 5.27 ± 2.14** | 6.21 ± 1.12MS | 86.44 ± 23.95 | 1.30 ± 0.54 | 4.69 ± 2.23 | 6.06 ± 0.79 | 99.35 ± 3.27 | 1.10 ± 0.48 | 4.38 ± 1.93 | 6.10 ± 0.48 |
| Metastatic tumors (5) | 92.00 ± 10.95 | 1.70 ± 0.76 | 5.90 ± 1.95 | 6.70 ± 0.76 | 100.00 ± 0.00 | 1.13 ± 0.63 | 4.50 ± 2.52 | 6.13 ± 0.63 | 96.00 ± 8.94 | 0.80 ± 0.45 | 3.10 ± 1.88 | 5.80 ± 0.45 |
| Necrotic malignant tumors (25) | 93.04 ± 22.25 | 1.17 ± 0.49 | 4.59 ± 1.97 | 5.91 ± 1.38 | 91.74 ± 17.23 | 1.35 ± 0.55 | 4.96 ± 2.17 | 6.22 ± 0.69 | 98.70 ± 4.58 | 1.15 ± 0.65 | 4.59 ± 2.61 | 6.15 ± 0.65 |
| Non-necrotic malignant tumors (29) | 99.00 ± 4.47 | 1.55 ± 0.60 | 6.05 ± 2.11** | 6.55 ± 0.60** | 80.91 ± 28.77 | 1.25 ± 0.53 | 4.41 ± 2.32 | 5.89 ± 0.87 | 100.00 ± 0.00 | 1.04 ± 0.21 | 4.17 ± 0.83 | 6.04 ± 0.21 |
Most relevant results are shown in bold.
** significantly (P<0.01) different from benign tumors.
MS marginally significantly (0.1<P<0.05) different from benign tumors.