Table 1. Enrichment p-values of antigen-presenting cell (APC) versus T cell interactions associated with type 1 diabetes.
APCs | T cells (E034) | Th naive (E038) | Th memory (E040) | Treg (E044) |
---|---|---|---|---|
Fetal thymus (E093) | 0.55 | 0.81 | 0.50 | 0.22 |
Monocytes (E029) | 4.9 × 10−4 | 0.016 | 2.7 × 10−4 | 4.2 × 10−6 |
B cells, PB (E032) | 8.4 × 10−9 | 1.4 × 10−5 | 4.4 × 10−9 | 2.7 × 10−12 |
B cells, CB (E031) | 1.8 × 10−5 | 2.9 × 10−3 | 1.3 × 10−5 | 7.5 × 10−8 |
The p-values signify the over-representation of interacting single-nucleotide polymorphism pairs active in each cell type combination. See Fig 4B. Shown in parentheses are the epigenome codes. PB, peripheral blood; CB, cord blood.