Fig 7. A61603 prevents cardiac cell death and myocardial fibrosis after DOX in WT male mice.

Male mice were treated with DOX or saline injection, and randomized to A61803 or Vehicle, as in Fig 4. Shown are indices at end of study for (A) Cardiac myocyte necrosis measured by serum CK activity in blood collected by LV puncture, and TUNEL staining for apoptosis in LV sections; and (B) LV myocardial fibrosis by sirius red staining. Number (n) is hearts; p by one-way ANOVA with Newman-Keuls multiple comparisons test.