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. 2017 Jan 12;12(1):e0169886. doi: 10.1371/journal.pone.0169886

Fig 4. Effect of nanoparticles (NPs) dose and size on gene promoter methylation upon exposure.

Fig 4

Bars connect exposure groups with significant methylation difference, a-d): effects of gold NPs (AuNPs) exposure dose on promoter methylation levels of Gsr (a, and b), Trp53 (c) in lungs, and Pparg (d) genes in blood. AuNPs size effect on CpG methylation of Trp53 gene was observed between 60 nm and 250 nm AuNPs. In panels, box plot describes the median (line across the box), inter-quartile range and maximum and minimum values (whiskers). Outliers are shown as colored circles outside the ends of whiskers. Asterisk sign (*) shows significance levels at p = 0.5 (dunn’s statistics). Gsr: glutathione reductase; Trp53: tumor protein P53; Pparg: peroxisome proliferator-activated receptor gamma.