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. 2017 Jan 12;12(1):e0169141. doi: 10.1371/journal.pone.0169141

Table 4. Effect of bufadienolides on HepG-2 and MKN-45 tumors.

Dosage Group HepG-2 MKN-45
Tumor weight(g) Inhibition(%) Tumor weight(g) Inhibition(%)
Blank 1.565±0.219 1.038±0.295
Cinobufacin 3.4 ml/kg 1.143±0.403 27.0 0.800±0.203 23.0
Bufadienolides 2.0 mg/kg 0.659±0.206*** 57.9 0.696±0.059* 33.0
Bufadienolides 0.5 mg/kg 1.109±0.373* 29.1 0.870±0.142 16.2

***P<0.001.

** P<0.01.

*P<0.05 compared to Cinobufacin group.