Table 2. Association between rs12970134 and rs17782313 and anthropometric measures.
| Variant | Phenotypes | MC4R genotypes | Adjusted | |||
|---|---|---|---|---|---|---|
| β or OR (95%CI) | P-value | |||||
| rs12970134 | GG (n = 1349) | GA (n = 718) | AA(n = 102) | |||
| BMI, kg/m2 (Mean (SD)) | 23.75(4.78) | 24.23(4.75) | 23.94(4.24) | 0.33(0.02, 0.63) | 0.034 | |
| Overweight/ obesity (%) | 1022(70.1) | 576(75.5) | 79(73.5) | 1.21(1.03, 1.44) | 0.025 | |
| rs17782313 | TT(n = 1202) | TC(n = 702) | CC(n = 126) | |||
| BMI, kg/m2 (Mean(SD)) | 23.70(4.90) | 23.98(4.70) | 24.05(4.29) | 0.06(-0.22, 0.34) | 0.687 | |
| Overweight /obesity (%) | 819(68.1) | 512(72.9) | 92(73.0) | 1.14(0.97, 1.35) | 0.120 | |
BMI, body mass index; OR, odds ratio; CI, confidence interval.
Effect sizes and P-values were estimated under additive genetic model adjusted for age, sex and study group in the combined analyses.