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. 2017 Jan 12;12(1):e0170062. doi: 10.1371/journal.pone.0170062

Table 3. The association study of rs12970134 and rs17782313 with obesity-related phenotypes.

rs12970134 rs17782313
n Estimate (95%CI) a P-value a P-value b n Estimate (95%CI) a P-value a P-value b
Height(cm) 2169 0.28(-0.22, 0.79) 0.274 - 2030 0.54(0.04, 1.03) 0.035 -
Weight(kg) 2169 0.88(-0.09, 1.85) 0.074 - 2030 0.40(-0.53, 1.32) 0.399 -
BMI-SDS 2169 0.07(-0.13, 0.14) 0.100 - 2030 0.03(-0.40, 0.11) 0.361 -
Waist circumference(cm) 2156 0.73(-0.06, 1.52) 0.070 0.744 2017 0.24(-0.50, 0.98) 0.521 0.476
Hip circumference(cm) 2154 0.66(0.04, 1.28) 0.038 0.783 2015 0.31(-0.28, 0.90) 0.299 0.134
Waist-to-Hip Ratio 2154 0.002(-0.002, 0.01) 0.333 0.634 2015 0.002(-0.002, 0.002) 0.911 0.856
Total Cholestestrol(mmol/L) 2169 -0.03(-0.09, 0.02) 0.242 0.126 2030 -0.03 (-0.097, 0.02) 0.190 0.172
Triglyceride(mmol/L) 2169 0.03(-0.01,0.07) 0.152 0.456 2030 -0.01(-0.05, 0.02) 0.472 0.363
LDL-C(mmol/L) 2169 0.01(-0.04, 0.06) 0.728 0.683 2030 0.002(-0.047, 0.051) 0.943 0.962
HDL-C(mmol/L) 2169 -0.03(-0.06, -0.01) 0.002 0.013 2030 -0.02 (-0.03, 0.003) 0.107 0.119
Systolic BP(mmHg) 2159 0.6(-0.40, 1.56) 0.237 0.941 2021 0.30(-0.64, 1.24) 0.533 0.602
Diastolic BP(mmHg) 2159 1.07(-0.19, 2.34) 0.096 0.329 2021 0.62(-0.43, 1.67) 0.245 0.265
Fasting glucose(mmol/L) 2169 -0.01(-0.05, 0.03) 0.653 0.861 2030 -0.01(-0.04, 0.03) 0.741 0.719
Body fat percentage (%) 1061 0.70(0.002, 1.40) 0.049 0.428 1071 0.36(-0.32, 1.05) 0.298 0.896
Metabolic syndrome 2153 1.05(0.90–1.23) 0.523 0.596 2015 0.91(0.77–1.06) 0.210 0.168

BMI, body mass index; BMI-SDS, BMI standard deviation score; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; BP, blood pressure; CI, confidence interval.

a Effect sizes and P-values were calculated adjusted for age, sex and study groups.

b P-values were calculated additionally adjusted for BMI.