Table 3. The association study of rs12970134 and rs17782313 with obesity-related phenotypes.
rs12970134 | rs17782313 | |||||||
---|---|---|---|---|---|---|---|---|
n | Estimate (95%CI) a | P-value a | P-value b | n | Estimate (95%CI) a | P-value a | P-value b | |
Height(cm) | 2169 | 0.28(-0.22, 0.79) | 0.274 | - | 2030 | 0.54(0.04, 1.03) | 0.035 | - |
Weight(kg) | 2169 | 0.88(-0.09, 1.85) | 0.074 | - | 2030 | 0.40(-0.53, 1.32) | 0.399 | - |
BMI-SDS | 2169 | 0.07(-0.13, 0.14) | 0.100 | - | 2030 | 0.03(-0.40, 0.11) | 0.361 | - |
Waist circumference(cm) | 2156 | 0.73(-0.06, 1.52) | 0.070 | 0.744 | 2017 | 0.24(-0.50, 0.98) | 0.521 | 0.476 |
Hip circumference(cm) | 2154 | 0.66(0.04, 1.28) | 0.038 | 0.783 | 2015 | 0.31(-0.28, 0.90) | 0.299 | 0.134 |
Waist-to-Hip Ratio | 2154 | 0.002(-0.002, 0.01) | 0.333 | 0.634 | 2015 | 0.002(-0.002, 0.002) | 0.911 | 0.856 |
Total Cholestestrol(mmol/L) | 2169 | -0.03(-0.09, 0.02) | 0.242 | 0.126 | 2030 | -0.03 (-0.097, 0.02) | 0.190 | 0.172 |
Triglyceride(mmol/L) | 2169 | 0.03(-0.01,0.07) | 0.152 | 0.456 | 2030 | -0.01(-0.05, 0.02) | 0.472 | 0.363 |
LDL-C(mmol/L) | 2169 | 0.01(-0.04, 0.06) | 0.728 | 0.683 | 2030 | 0.002(-0.047, 0.051) | 0.943 | 0.962 |
HDL-C(mmol/L) | 2169 | -0.03(-0.06, -0.01) | 0.002 | 0.013 | 2030 | -0.02 (-0.03, 0.003) | 0.107 | 0.119 |
Systolic BP(mmHg) | 2159 | 0.6(-0.40, 1.56) | 0.237 | 0.941 | 2021 | 0.30(-0.64, 1.24) | 0.533 | 0.602 |
Diastolic BP(mmHg) | 2159 | 1.07(-0.19, 2.34) | 0.096 | 0.329 | 2021 | 0.62(-0.43, 1.67) | 0.245 | 0.265 |
Fasting glucose(mmol/L) | 2169 | -0.01(-0.05, 0.03) | 0.653 | 0.861 | 2030 | -0.01(-0.04, 0.03) | 0.741 | 0.719 |
Body fat percentage (%) | 1061 | 0.70(0.002, 1.40) | 0.049 | 0.428 | 1071 | 0.36(-0.32, 1.05) | 0.298 | 0.896 |
Metabolic syndrome | 2153 | 1.05(0.90–1.23) | 0.523 | 0.596 | 2015 | 0.91(0.77–1.06) | 0.210 | 0.168 |
BMI, body mass index; BMI-SDS, BMI standard deviation score; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; BP, blood pressure; CI, confidence interval.
a Effect sizes and P-values were calculated adjusted for age, sex and study groups.
b P-values were calculated additionally adjusted for BMI.