Figure 2. Interneuron activity regulates transmitter release at the same synapses depending on the firing rate.
(A) Synaptic efficacy, success rate and synaptic potency before and after pairing SC stimuli with single (red) or bursts (blue) of interneuron APs (n = 6). Horizontal bars indicate the time of pairing. (B) Raw values of synaptic parameters plotted for both IN-stimulation conditions: control (black), IN single AP (red), and IN burst (blue) stimulation (n = 6). Note that the IN-mediated effects were independent on the initial values of synaptic parameters. (C) Relative changes of synaptic parameters from basal (black) elicited by pairing SC stimuli with single (red) or bursts of interneuron APs (blue) (n = 6). Synaptic efficacy: p=0.008 (red), p<0.001 (blue). Synaptic potency: p=0.355 (red), p=0.407 (blue). Success rate: p<0.001 (red), p<0.001 (blue); paired t test. **p<0.01, #p<0.001; paired t test.