(
A) Averaged relative changes of success rate over time during a stimulation paradigm consisting of SC stimuli at 3 Hz and bursts of interneuron APs (top panel schemes, and described in
Figure 5), when SC stimuli coincided with the interneuron up-state, i.e., during the interneuron bursts of APs (
n = 6,
left), or down-state, i.e., during the resting state between two consecutive interneuron bursts of APs (
n = 5;
right). (
B) Relative changes of synaptic parameters for conditions shown in
A. Synaptic efficacy
up: p<0.001; paired
t test. Synaptic efficacy
down: p<0.001; paired
t test. Synaptic efficacy
up vs
down: p=0.016; unpaired
t test. (
C) Relative changes of success rate over time for up-EPSCs and down-EPSCs, without interneuron stimulation, evoked by SC stimulation at 3 Hz (
n = 8) and 6 Hz (
n = 11). (
D) Relative values of synaptic parameters in the absence of interneuron stimulation. SC stimulation 3 Hz (
n = 8; p>0.05; paired
t test) and 6 Hz (
n = 11; p>0.05; paired
t test). *p<0.05, **p<0.01, ***p<0.001. Error bars indicate SEM.