Figure 5.

Best (left) and worst (right) registration with the SPM template (middle) as selected from visual inspection.

All registrations were similar but in the worst case the most superior GM regions were more flattened, most probably due to the greater atrophy of the particular subject compared to the template. Thus, the worst template registration would still detect this atrophy, but might overestimate the true degree of GM atrophy in this subject.