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. 2017 Jan 15;28(2):285–295. doi: 10.1091/mbc.E16-07-0526

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© 2017 Szíber et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 2: — (A) Representative dendritic outlines of EGFP-expressing CD1 and Rin1⁻^/⁻ hippocampal neurons on DIV13. (B) Dendritic branches of Rin1⁻^/⁻ hippocampal neurons expressing EGFP, RIN1^WT-EGFP, or RIN1^S351A-EGFP for 24 h. (C) Average protrusion density and (D) ratio of stubby, mushroom-like or filamentous spines within the transfected hippocampal neurons. (E) pCrkL levels in HEK293T cells transfected with EGFP-tagged wild-type RIN1, RIN1^S351A, RIN1^QM, or RIN1^E574A constructs. Anti-GFP signal indicates similar expression levels of RIN1 constructs. α-Tubulin served as a loading control. Data are presented as mean ± SEM. *p < 0.05; **p < 0.01. Asterisk represents significant differences compared with control values. Arrows indicate filamentous protrusions; arrowheads show mushroom-type dendritic spines. Scale bar, 50 μm (A), 1 μm (B).