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. 2017 Jan 15;28(2):285–295. doi: 10.1091/mbc.E16-07-0526

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© 2017 Szíber et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 4: — Transferrin uptake in pulse-labeled Rin1⁻^/⁻ hippocampal neurons. (A) Fluorescently labeled transferrin signals associated with the plasma membrane (surface) or internalized after 1 or 5 min of chasing time. Red arrowheads show surface-localized transferrin puncta; empty arrowheads indicate internalized transferrin signals; dashed line indicates plasma membrane. The xyz-planes are represented in cut-view images (top). Scale bars, 1 μm (cut views), 5 μm (overviews). (B) The ratio of internalized transferrin signals compared with the total number of transferrin-positive puncta visible in the equatorial plane of the neuronal soma in Rin1⁻^/⁻ neurons transfected with the indicated fluorescently tagged constructs. Data are presented as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.