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. 2017 Jan;58(1):96–105. doi: 10.1167/iovs.16-20339

Figure 2.

Figure 2

Effect of anti-TNF-α DDS in reducing CNV and opacification after alkali burn. Photographs of the rabbit eyes treated with anti-TNF-α DDS (A–C) and with sham DDS (D–F) 3 months after corneal alkali burn. (G, H) Although not statistically significant, anti-TNF-α DDS treated rabbits had smaller areas of CNV compared to sham DDS treated (P = 0.228; mixed ANOVA). Similar progression patterns were found from the single-masked assessment of CNV (P = 0.131; mixed ANOVA). (I, J) Independent, single-masked assessment of central and peripheral corneal opacity showed that anti-TNF-α DDS treated rabbits had similar central corneal opacity as the sham DDS group, but accelerated peripheral corneal clearance compared to sham DDS treated, which exhibited persistent corneal opacity (P < 0.05; mixed ANOVA). Opacity score ranges from 0 to 4 (0 = clear, 4 = opaque).