Figure 4.
(A) Representative PLRs of older dogs bearing mutations in PDE6B, RD3, STK38L, and PRCD. Recordings from all dogs with mutations in STK38L, IQCB1, RPGR, RPE65, and PRCD and older dogs carrying PDE6B, RD3, and PDE6A-mutations are shown in Supplementary Figure S4. Shaded area represents the 1-s light stimulus presentation. ★ indicates absent PLR to scBB in one older STK38L-mutant. Arrows indicate small residual rod function and near-normal preserved cone function in an older dog with mutated PRCD. (B) Representative full-field ERGs recorded from older dogs bearing mutations in PDE6B, STK38L, and PRCD. Responses of a WT dog are shown for comparison. For PDE6B- and STK38K-mutant dogs, rod- and cone- mediated function was non-recordable. For the PRCD-mutant dog, cone-mediated function was recordable, but the amplitude was reduced compared with that of the WT dog. (A) Calibration bars: 1 s (time, horizontal) and 20% (normalized pupil size, vertical).