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Ang-2 blockade markedly inhibited lymphatic formation in grafted corneas. (A) Representative whole-mount images showing significant reduced lymphatic vessels in anti-Ang-2–treated corneas 8 weeks after transplantation. Fewer blood vessels were observed in the treated corneas but to a less degree. Green: LYVE-1; Red: CD31. Scale bar: 1 mm. (B) Summarized data in vascular coverage area. ***P < 0.001; *P < 0.05. LV, lymphatic vessel; BV, blood vessel.
