Table 1. Model Parameters.
| Input Variable | Parameter | (Range or S.E.) | Source |
|---|---|---|---|
| Rates and Probabilities | |||
| 1-year probability of CVD event | |||
| From Framingham study | |||
| MI | 0.14%-1.16% | (age dependent) | D’Agostino et al. |
| Stroke | 0.08%-0.63% | (age dependent) | D’Agostino et al. |
| Other CVD | 0.23%-1.65% | (age dependent) | D’Agostino et al. |
| From Sabatine et al. study | |||
| MI | 0.30%-1.68% | (age dependent) | Sabatine et al. |
| Stroke | 0.05%-0.28% | (age dependent) | Sabatine et al. |
| Other CVD | 0.25%-1.40% | (age dependent) | Sabatine et al. |
| 1-year probability of sub-sequent CVD event | |||
| MI | 0.48%-1.86% | (age dependent) | D’Agostino et al. |
| Stroke | 0.32%-1.02% | (age dependent) | D’Agostino et al. |
| Other CVD | 0.93%-2.83% | (age dependent) | D’Agostino et al. |
| Mortality rates | |||
| After MI | 8.2%-98.5% | (age dependent) | CDC |
| After Stroke | 5.9%-93.4% | (age dependent) | CDC |
| After other CVD | 7.0%-96.0% | (age dependent) | CDC |
| After post-MI | 3.6%-67.3% | (age dependent) | Bronnun et al. |
| After post-Stroke | 3.3%-60.9% | (age dependent) | Bronnun et al. |
| After post-other CVD | 3.4%-64.1% | (age dependent) | Bronnun et al. |
| Non CVD related | 0.5%-18.3% | (age dependent) | CDC |
| Costs | |||
| Statin treatment | $48 | ($36–$60) | Erickson et al. |
| PCSK9 treatment | $12,048 | ($9,036–$15,060) | |
| Baseline treatment | $215 | ($161–$269) | Davis et al. |
| MI | $11,071 | ($8,303–$13,839) | Erickson et al. |
| Post-MI | $7,747 | ($5,810–$9,684) | Erickson et al. |
| Stroke | $18,516 | ($13,887–$23,145) | Erickson et al. |
| Post-Stroke | $7,770 | ($5,828–$9,713) | Erickson et al. |
| Other CVD | $14,794 | ($11,095–$18,492) | Erickson et al. |
| Post–other CVD | $7,759 | ($5,819–$9,698) | Erickson et al. |
| Utility | |||
| Statin/PCSK9 treatment | 0.79 | Sullivan at al. | |
| MI (range over 5 years) | 0.58–0.79 | (0.54, 0.91) | Sullivan at al. |
| Stroke (range over 5 years) | 0.46–0.79 | (0.52, 0.87) | Sullivan at al. |
| Other CVD (range over 5 years) | 0.63–0.79 | (0.57, 0.96) | Sullivan at al. |
| Dead | 0 | ||
| Health insurance parameters | |||
| Premium | |||
| Age | |||
| 58–64 | $223–$520 | (age dependent) | eHealth 2014 |
| 65+ | $835 | ($751.6, $1,043.9) | CMS 2014 |
| Deductible | |||
| Age | |||
| 58–64 | $3,882–$3,731 | (age dependent) | eHealth 2014 |
| 65+ | $2,158 | ($1,942.2, $2,697.5) | CMS 2014 |
| Tier 1 | |||
| Age | |||
| 58–64 | 11 | (9.9, 13.75) | eHealth 2014 |
| 65+ | 5 | (4.5, 6.25) | CMS 2014 |
| Tier 2 | |||
| Age | |||
| 58–64 | 31 | (27.9, 38.75) | eHealth 2014 |
| 65+ | 11 | (9.9, 13.75) | CMS 2014 |
| Turnover rate | 12.20% | (0.71%) | Cutler et al. |