Figure 5.

Clustering multiple ETS sites within an element increases occupancy at the sites. One ETS site is held fixed, whereas another ETS site is moved from the adjacent position (orange) to the most distal position (purple). The plotted fractional occupancies are measured at the fixed ETS site as a function of concentration. Dashed lines denote fractional occupancy at the fixed site without an additional ETS site in the system. (A) Fractional occupancy with the wild-type parameters of Yan. (B) Fractional occupancy when the protein-protein interaction term is set to 0 kcal/mol. Note that all lines are identical in fractional occupancy and plotted on top of one another.