FIG. 7.

Modulation of C-mer activity does not affect R-mediated lytic gene expression. EBV-positive D98/HE-R-1 cells were transfected with the SG5 or SG5-R vectors, in combination with either a control vector, a vector that inhibits C-mer signaling in the presence of EGF (Mer-KD), or a vector that activates a C-mer-like pathway in the presence of EGF (C-mer). EGF was added 24 h after transfection to some conditions, and cells were harvested 48 h posttransfection for immunoblot analysis to detect lytic EBV gene expression.