FIG. 2.

Clustering of genes perturbed by HIV-1 infection of MDM. (A) Hierarchical agglomerative clustering of ∼900 genes was based on expression patterns over time. Median induction (red) or repression (green) of expression ranged between +4 and −4 for each gene. Genes were distributed into nine cluster patterns designated A to I (color coded on the right [y] axis of the dendrogram). (B) Median induction or repression (n-fold) over time for ∼800 genes in six clusters ranged between +2- and −2-fold. Three patterns of induction of gene expression were observed: early (day 2; clusters C, H, and I), intermediate (day 4; clusters B and E), and late (day 7; cluster D).