FIG. 1.
Distribution of ASV integration events in human chromosomes. Results are plotted as the percentage of integration events in each chromosome (n = 226). The parameters used to calculate the relative target size of each chromosome included the estimated size (19, 38) as well as corrections for differential chromosome aneuploidies, minute chromosomes, and translocations. For these corrections we used the HeLa cell karyotype and chromosome composition analyses described by Macville et al. (21). The hypothesis that the number of integration sites is proportional to chromosome length could not be rejected (χ2 = 27.6, 22 df, P = 0.194).