TABLE 2.
Percentage of ASV integration events with respect to RefSeq gene structure
| Location | % of integrationsa
|
|||
|---|---|---|---|---|
| ASV | MLVb | HIV-1b | Randomb | |
| 5 kb upstream of genes | 4.4c | 11.2 | 2.9 | 2.1 (2.5)d |
| ±5 kb from transcription start | 8.4c | 20.2e | 10.8e | 4.3 (5.1)d |
| ±1 kb from CpG islands | 3.1f | 16.8e | 2.1 | 2.1 |
a
Values for ASV and MLV were found to be significantly different (P ≤ 0.0034).
b
Data from the work of Wu et al. (43).
c
Distinguishable from random integration (P ≤ 0.02) by using one-sided test of the binomial proportion.
d
Values in parentheses indicate expected proportional increase in RefSeq targets by using the July 2003 assembly versus the November 2002 assembly used by Wu et al. (43).
e
Distinguishable from random integration, as described by Wu et al. (43).
f
Value is indistinguishable from random value (P = 0.869) by one-sided test of the binomial proportion.