Table 9.

The neighbors of candidate drug “MS-257” on the validation network.

Genes	Description	Weight
HDAC1	Histone deacetylase 1; responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, and developmental events.	0.987
TP53	Tumor protein p53: it acts as a tumor suppressor in many tumor types and induces growth arrest or apoptosis depending on the physiological circumstances and cell type.	0.831
CASP3	Caspase 3, apoptosis-related cysteine peptidase; involved in the activation cascade of caspases responsible for apoptosis execution.	0.827
CCND1	cyclin D1; essential for the control of the cell cycle at the G1/S (start) transition.	0.822
CYP3A4	Cytochrome P450, family 3, subfamily A, polypeptide 4; cytochromes P450 are a group of heme-thiolate monooxygenases.	0.433