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A) Primary sequence of human CYP3A4 used here (referred to as the wild-type). Theoretical Cys-containing BrCN digestion peptides are underlined, and their approximate molecular weight when labelled with 10 is shown with the sequence number of the cysteine residue included in each peptide. B) Crystal structure of CYP3A4 (PDB: 1TQN) with cysteine residues highlighted in red.
