Table 2.

Effect of 12-week treatment with SCH 57068 on body weight gain, uterine wet weight, serum HDL and triglyceride levels in the ovariectomized rat

Group	Body weight gain (g)	Uterine weight (mg)	HDL (mM)	Triglycerides (mM)
Intact	0.9 ± 3.6a	652 ±23a	1.98 ±0.10a	0.60 ±0.08
OVX	33.3 ± 2.7	171 ±5	2.55 ±0.07	0.57 ±0.04
OVX + SCH57068 (0.01 mg/kg)	12.5 ± 2.6a	184 ±7	1.67 ±0.04a	0.63 ±0.03
OVX + SCH57068 (1 mg/kg)	10.8 ± 2.6a	167 ±2	1.60 ±0.06a	0.71 ±0.07
OVX + SCH57068 (2.5 mg/kg)	10.4 ± 2.5a	160 ±3	1.68 ±0.04a	0.66 ±0.07
OVX + E2	−12.0 ± 3.7	533 ±19	2.35 ±0.06	0.43 ±0.03
OVX + E2 +SCH57068 (0.01 mg/kg)	−15.9 ± 1.6	530 ±21	2.12 ±0.11b	0.51 ±0.03
OVX + E2+ SCH57068 (1 mg/kg)	−16.3 ± 3.1	308 ±14b	1.63 ±0.04b	0.43 ±0.04
OVX + E2+ SCH57068 (2.5 mg/kg)	−16.7 ± 4.8	241 ±6b	1.70 ±0.04b	0.39 ±0.03

Data are mean ±S.E.M. of 9–12 animals.

^aP < 0.0001 vs. OVX rats.

^bP < 0.0001 vs. OVX + E₂ rats.