Table 1.
Study population baseline characteristics by ACR
| Demographics | HIV infected women | HIV uninfected women | ||||
|---|---|---|---|---|---|---|
| ACR≤30 mg/g (N=670) |
ACR>30 mg/g (N=153) |
P- value |
ACR≤30 mg/g (N=247) |
ACR>30 mg/g (N=20) |
P- value |
|
| Age (years) | 40 (36–45) | 41 (36–46) | 0.10 | 39 (33–44) | 42 (37–46) | 0.19 |
| Race | ||||||
| African American | 358 (53%) | 101 (66%) | 0.01 | 148 (60%) | 12 (60%) | 0.57 |
| Caucasian | 144 (21%) | 21 (14%) | 30 (12%) | 1 (5%) | ||
| Other | 168 (25%) | 31 (20%) | 69 (28%) | 7 (35%) | ||
| Menopause | 122 (18%) | 41 (27%) | 0.02 | 26 (11%) | 2 (11%) | 0.99 |
| Current smoking | 336 (50%) | 79 (52%) | 0.52 | 139 (57%) | 14 (74%) | 0.33 |
| Diabetes mellitus | 139 (21%) | 39 (25%) | 0.20 | 59 (24%) | 10 (53%) | <0.01 |
| HOMA-IR | 2.8 (2.0–4.1) | 3.4 (2.4–5.6) | <0.01 | 2.7 (1.9–4.2) | 3.7 (2.2–6.5) | 0.10 |
| Systolic blood pressure (mmHg) | 115 (107–122) | 121 (111–130) | <0.01 | 117 (110–127) | 124 (114–133) | 0.15 |
| Diastolic blood pressure (mmHg) | 72 (67–77) | 77 (71–82) | <0.01 | 73 (67–80) | 76 (67–81) | 0.46 |
| LDL cholesterol (mg/dL) | 101 (87–113) | 103 (89–118) | 0.06 | 106 (93–120) | 108 (100–115) | 0.90 |
| HDL cholesterol (mg/dL) | 49 (43–54) | 46 (41–53) | 0.02 | 53 (47–59) | 51 (46–59) | 0.63 |
| TG (mg/dL) | 137 (114–168) | 156 (125–189) | <0.01 | 129 (101–155) | 124 (97–160) | 0.86 |
| BMI (kg/m2) | 26 (23–30) | 27 (23–31) | 0.92 | 29 (24–34) | 33 (25–37) | 0.27 |
| Waist Circumference (cm) | 87 (79–97) | 88 (79–102) | 0.44 | 92 (80–100) | 96 (79–109) | 0.27 |
| Active hepatitis C | 204 (30%) | 48 (31%) | 0.83 | 52 (21%) | 3 (16%) | 0.57 |
| Current stimulant use | 76 (11%) | 12 (8%) | 0.21 | 41 (17%) | 5 (26%) | 0.29 |
| eGFR (ml/min/1.73m2) | 92 (78–106) | 81 (66–96) | <0.01 | 103 (91–117) | 102 (88–108) | 0.46 |
| HAART use | 398 (59%) | 86 (56%) | 0.47 | |||
| NRTI use | 453 (68%) | 93 (61%) | 0.11 | |||
| NNRTI use | 181 (27%) | 47 (31%) | 0.36 | |||
| PI use | 287 (43%) | 58 (38%) | 0.27 | |||
| Current CD4 | 391 (246–555) | 384 (168–624) | 0.58 | |||
| Nadir CD4 | 222 (122–337) | 212 (97–339) | 0.46 | |||
| History of AIDS | 353 (53%) | 82 (54%) | 0.84 | |||
| HIV viral load | 203 (30%) | 41 (27%) | <0.01 | |||
| <=80 | ||||||
| 81–1,999 | 162 (24%) | 22 (15%) | ||||
| 2,000–9,999 | 115 (17%) | 24 (16%) | ||||
| >10,000 | 187 (28%) | 63 (42%) | ||||
Note: Data are presented as median (interquartile range) or percentage.
Abbreviations: ACR, albumin-creatinine ratio; LDL, low-density lipoprotein; HDL, high-density lipoprotein; TG, triglyceride; BMI, body mass index; NRTI, nucleoside reverse transcriptase inhibitor; HAART, highly active antiretroviral therapy; HOMA-IR, insulin resistance; NNRTI, nonnucleoside reverse transcriptase inhibitor; PI, protease inhibitor; AIDS, acquired immunodeficiency syndrome; HIV, human immunodeficiency virus; eGFR, estimated glomerular filtration