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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: J Clin Pharmacol. 2016 Aug 23;57(2):219–229. doi: 10.1002/jcph.796

Table 2.

Significant covariates for the univariate and multivariate analyses

Significant covariates ΔMOFV p-value
Univariate analysis
Effect of GLU on V/F −4.674 <0.05
Effect of eGFR on CL/F −6.658 <0.01
Effect of LAMF on ka1 −6.587 <0.01
Multivariate analysis
Effect of eGFR on CL/F 52.145 <0.001

MFOV, minimum objective function; GLU, glucose; V/F, apparent volume of distribution; eGFR, estimated glomerular filtration rate; CL/F, apparent total clearance of metformin; LAMF, left arm fat; ka1, absorption rate constant at the first absorption site