Table 2.

Metronidazole Clearance, Hydroxyl-Metronidazole Area Under the Curve, Metronidazole Area Under the Curve, and Metabolic Ratio for Each Infant

CYP2A6 Genotype	Postmenstrual Age (weeks)	Body Weight (kg)	Clearance (L/hr/kg)	Hydroxy-metronidazole AUC0-τ (μM*h)	Metronidazole AUC0-τ (μM*h)	Metabolic Ratioa
*1/ *1	24.71	0.61	0.02	443.49	2091.73	0.21
*1/ *1	25.14	0.75	0.01	26.72	2325.45	0.01
*1/ *1	30.28	1.31	0.06	74.81	683.61	0.11
*1/ *1	23.85	0.57	0.02	NE	2161.85	—
*1/ *1	29.57	1.34	0.02	128.24	1343.85	0.10
*1/ *1	33.28	1.09	0.10	363.34	385.63	0.94
*1/ *1	32.00	0.93	0.04	64.12	870.58	0.07
*1/ *1	34.86	1.56	0.04	58.78	946.54	0.06
*1/ *1	35.29	1.96	0.08	154.96	584.28	0.27
*1/ *1	33.57	1.76	0.04	NE	NE	—
*1/ *1	31.15	1.35	0.04	NE	NE	—
*1/ *1	33.86	1.64	0.04	106.87	1051.71	0.10
*1/ *17	26.71	0.69	0.04	NE	858.90	—
*1/ *17	29.43	0.96	0.03	101.52	1051.71	0.10

AUC, area under the curve; NE, not estimated.

^aMetabolic ratio = $\frac{\text{AUC metabolite}}{\text{AUC parent}}.$