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. Author manuscript; available in PMC: 2017 Mar 27.
Published in final edited form as: Pediatr Res. 2016 Sep 27;81(1-2):202–209. doi: 10.1038/pr.2016.198

Figure 1.

Figure 1

Schematic diagram showing the phases of primary and secondary energy failure after hypoxia-ischemia on magnetic resonance spectroscopy (MRS), and the amelioration of secondary energy failure with therapeutic hypothermia started during the latent phase after transient hypoxia-ischemia in a newborn piglet. Upper panel shows phosphorus-31 MRS NTP/EPP peak area ratio at baseline, during and after hypoxia-ischemia. The preservation of high energy phosphates with hypothermia versus normothermia is shown on the diagram (blue line versus red line) and in the representative spectra at 48 h (red normothermia, blue hypothermia). Lower panel shows proton MRS lactate/NAA peak area ratio at baseline, and during and after hypoxia-ischemia. The amelioration of the rise in lactate/NAA with hypothermia versus normothermia is shown on the diagram (blue line versus red line) and in the representative spectra at 48 h (red normothermia, blue hypothermia). NTP: nucleotide tri-phosphate; EPP: exchangeable phosphate pool; NAA: N-acetyl aspartate.