Table 3.

Model coefficients for longitudinal analysis

	5 years of follow-up				7 years of follow-up
	Model 1: 6 months thru 5 years		Model 2: 1 year thru 5 years		Model 3: 6 months thru 7 years		Model 4: 1 year thru 7 years
Model term	Coefficient (95 % CI)	P value	Coefficient (95 % CI)	P value	Coefficient (95 % CI)	P value	Coefficient (95 % CI)	P value
Intercept	52.59 (35.90 to 69.28)	<.0001	59.04 (41.42 to 76.65)	<.0001	55.61 (39.32 to 71.89)	<.0001	60.89 (43.70 to 78.08)	<.0001
Treatment (main effect)	−16.58 (−23.69 to −9.47)	<.0001	3.59 (−1.05 to 8.24)	.13	−13.51 (−19.65 to −7.37)	<.0001	3.28 (−1.24 to 7.81)	.16
Time (main effect)	3.60 (−0.23 to 7.94)	.07	0.66 (−0.12 to 1.44)	.10	2.00 (−0.43 to 4.43)	.11	0.53 (0.04 to 1.01)	.03
Treatment by time (linear interaction)	13.25 (7.43 to 19.06)	<.0001			9.22 (5.74 to 12.69)	<.0001
Time by Time (quadratic term)	−0.54 (−1.29 to 0.21)	.16			−0.15 (−0.49 to 0.18)	.37
Treatment by time × time (quadratic interaction)	−1.84 (−2.91 to −0.78)	.0007			−1.05 (−1.53 to −0.57)	<.0001
Baseline energy/vitality	0.23 (0.10 to 0.35)	.0004	0.22 (0.09 to 0.36)	.002	.22 (0.10 to 0.34)	.0006	0.21 (0.08 to 0.34)	.002
Baseline PS	1.07 (−7.83 to 9.97)	.81	0.58 (−9.19 to 10.36)	.91	1.55 (−7.25 to 10.34)	.73	0.92 (−8.67 to 10.51)	.85
Baseline CARESPHYS	−4.13 (−10.48 to 2.22)	.20	−5.32 (−12.43 to 1.80)	.14	−3.73 (−9.97 to 2.52)	.24	−4.73 (−11.65 to 2.20)	.18
Baseline SDS	−0.70 (−1.29 to −0.12)	.02	−0.79 (−1.42 to −0.15)	.02	−0.77 (−1.35 to −0.20)	.009	−0.84 (−1.47 to −0.22)	.009

PS performance status, CARESPHYS Cancer Rehabilitation Evaluation System-Short Form Physical score, SDS symptom distress scale