Dx is less effective from the apical side (pooled data)
Bath Dx 20–200 μm depolarized V
t (A), V
b (B) and V
a (C), increased R
t (D), and reduced I
sc (E) and R
a/R
b ratio (F). Luminal Dx at 20 μm is ineffective. Number of experiments (n) indicated in A is the same for B–F. Graphs show mean ± SEM. *
P < 0.05, **
P < 0.01, ***
P < 0.001.