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. 2016 Jun 17;595(2):505–521. doi: 10.1113/JP272208

Figure 5. Restoration of ATP did not prevent epithelial necroptosis or mucosal histopathology in ischaemic gut.

Figure 5

Isch rats were enterally administered ATP‐loaded liposomes (ATP) or empty liposomes (Empty). A, intracellular ATP levels were measured in the gut mucosa of Isch rats. * P < 0.05 vs. Empty (n = 6 per group). B, immunoprecipitation blotting showed the formation of RIP1‐RIP3 complex in jejunal mucosa of Isch rats enterally instilled with liposomal ATP. The experiments were repeated twice and similar results were obtained (n = 3 per group). C, representative photoimages of the histological changes in CON and Isch intestines with ATP or empty liposomes. Administration of liposomal ATP did not protect against morphological damage. Magnification 200×. D, histopathological scores in the jejunal tissues of CON and Isch rats administered liposomal ATP or empty controls. * P < 0.05 vs. respective CON (n = 6 per group). [Colour figure can be viewed at wileyonlinelibrary.com]