Figure 2. Enteric glial cells derive from neural crest precursors and mature into neuroglia in the enteric nervous system.

Enteric glia within the myenteric plexus are slowly replaced under physiological conditions (Joseph et al. 2011; Laranjeira et al. 2011) and are responsible for generating glia that migrate to the intestinal mucosa (Kabouridis et al. 2015).