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. 2016 May 29;595(2):557–570. doi: 10.1113/JP271021

Table 3.

Enteric glia cell (EGC)‐derived molecules that regulate intestinal epithelial function

Molecule Effect on GI epithelium Source References
TGF‐β1 ↓ Proliferation In vitro (Caco‐2 and primary EGCs, MP derived) (Neunlist et al. 2007)
GSNO ↓ Permeability In vitro, in vivo, human tissue (Savidge et al. 2007)
15dPGJ2 ↓ Proliferation In vitro (Caco‐2 and primary EGCs, MP derived) (Bach‐Ngohou et al. 2010)
GDNF* ↓ Permeability In vivo (Zhang et al. 2010)
proEGF ↑ Wound healing In vitro (Caco‐2 and EGC lines) (Van Landeghem et al. 2011)

Abbreviations: 15dPGJ2, 15‐deoxy‐Δ12,14‐prostaglandin J2; Caco‐2, human epithelial colorectal adenocarcinoma cell line; GDNF, glial‐derived neurotrophic factor; GSNO, S‐nitrosoglutathione; proEGF, pro‐epidermal growth factor precursor; TGF‐β1, transforming growth factor β1. *Release of GDNF was not directly associated to EGCs.