Table 3.
Molecule | Effect on GI epithelium | Source | References |
---|---|---|---|
TGF‐β1 | ↓ Proliferation | In vitro (Caco‐2 and primary EGCs, MP derived) | (Neunlist et al. 2007) |
GSNO | ↓ Permeability | In vitro, in vivo, human tissue | (Savidge et al. 2007) |
15dPGJ2 | ↓ Proliferation | In vitro (Caco‐2 and primary EGCs, MP derived) | (Bach‐Ngohou et al. 2010) |
GDNF* | ↓ Permeability | In vivo | (Zhang et al. 2010) |
proEGF | ↑ Wound healing | In vitro (Caco‐2 and EGC lines) | (Van Landeghem et al. 2011) |
Abbreviations: 15dPGJ2, 15‐deoxy‐Δ12,14‐prostaglandin J2; Caco‐2, human epithelial colorectal adenocarcinoma cell line; GDNF, glial‐derived neurotrophic factor; GSNO, S‐nitrosoglutathione; proEGF, pro‐epidermal growth factor precursor; TGF‐β1, transforming growth factor β1. *Release of GDNF was not directly associated to EGCs.