Table 3. Differences in duration of breastfeeding associated with a doubling of the maternal serum-PFAS concentrations.
| Model 1 a | Model 2 a b c | Model 3 a b d | Model 4 b c e | |||||
|---|---|---|---|---|---|---|---|---|
| Primiparous | Multiparous | Older cohort | Younger cohort | |||||
|
| ||||||||
| Total breastfeeding (months) | ||||||||
|
| ||||||||
| Difference (95 % CI) | Difference (95 % CI) | Difference (95 % CI) | Difference (95 % CI) | p i | Difference (95 % CI) | Difference (95 % CI) | p i | |
| N=998 | N=987 | N=987 | N=987 | |||||
| PFHx S | -0.1 (-0.5; 0.2) | -0.2 (-0.5; 0.2) | -0.1 (-0.5; 0.3) | -0.2 (-0.5; 0.2) | 0.66 | -0.2 (-0.7; 0.2) | -0.1 (-0.6; 0.4) | 0.75 |
| PFOS | -1.4 (-2.1; -0.6) | -1.4 (-2.1; -0.6) | -1.3 (-2.3; -0.3) | -1.4 (-2.2; -0.7) | 0.75 | -2.2 (-3.5; -0.8) | -1.0 (-1.9; -0.1) | 0.14 |
| PFOA | -1.6 (-2.1; -1.0) | -1.3 (-1.9; -0.7) | -1.1 (-2.0; -0.1) | -1.4 (-2.0; -0.8) | 0.45 | -1.8 (-3.0; -0.7) | -1.1 (-1.7; -0.4) | 0.21 |
| PFNA | -1.0 (-1.6; -0.3) | -1.3 (-2.0; -0.7) | -1.6 (-2.6; -0.6) | -1.2 (-2.0; -0.5) | 0.60 | -1.8 (-2.8; -0.9) | -0.7 (-1.5; -0.0) | 0.07 |
| PFDA | -0.4 (-1.0; 0.2) | -0.8 (-1.4; -0.3) | -1.6 (-2.6; -0.7) | -0.5 (-1.2; 0.1) | 0.06 | -1.2 (-2.0; -0.5) | -0.3 (-1.1; 0.5) | 0.10 |
|
| ||||||||
| Exclusivebreastfeeding (months) | ||||||||
|
| ||||||||
| Difference (95 % CI) | Difference (95 % CI) | Difference (95 % CI) | Difference (95 % CI) | p i | Difference (95 % CI) | Difference (95 % CI) | p i | |
|
| ||||||||
| N=997 | N=986 | N=986 | N=986 | |||||
| PFHx S | -0.0 (-0.2; 0.1) | -0.1 (-0.2; 0.1) | -0.0 (-0.1; 0.1) | -0.1 (-0.2; 0.0) | 0.28 | -0.1 (-0.2; 0.1) | -0.0 (-0.2; 0.1) | 0.91 |
| PFOS | -0.4 (-0.7; -0.1) | -0.3 (-0.6; -0.1) | -0.2 (-0.6; 0.1) | -0.3 (-0.6; -0.1) | 0.52 | -0.4 (-0.8; 0.1) | -0.3 (-0.6; -0.0) | 0.88 |
| PFOA | -0.6 (-0.8; -0.4) | -0.5 (-0.7; -0.3) | -0.4 (-0.8; 0.0) | -0.5 (-0.7; -0.3) | 0.55 | -0.6 (-0.9; -0.2) | -0.4 (-0.7; -0.2) | 0.52 |
| PFNA | -0.2 (-0.4; -0.0) | -0.2 (-0.5; -0.0) | -0.3 (-0.8; 0.1) | -0.2 (-0.4; 0.0) | 0.64 | -0.2 (-0.5; 0.1) | -0.3 (-0.6; 0.0) | 0.76 |
| PFDA | -0.1 (-0.3; 0.1) | -0.2 (-0.4; 0.0) | -0.5 (-0.9; -0.1) | -0.1 (-0.3; 0.1) | 0.06 | -0.1 (-0.3; 0.2) | -0.3 (-0.6; -0.0) | 0.27 |
a
Adjusted for cohort
b
Adjusted for maternal age, pre-pregnancy BMI, pregnancy alcohol intake, pregnancy smoking, education, and employment
c
Adjusted for parity
d
Interaction between parity and PFAS
e
Interaction between cohort and PFAS
i
p-value for interaction