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. 2016 Dec 23;15:193–202. doi: 10.1016/j.ebiom.2016.12.011

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Overall phenotype of the Col6a1^GT/GT mice.

(a) Growth curves of female: control littermates (black, n = 5–113 per aged group) and Col6a1^GT/GT (red, n = 5–54 per aged group). (b) Growth curves of male: control littermates (black, n = 5–114 per aged group) and Col6a1^GT/GT (red, n = 5–59 per aged group). (c) Grip power of female: control littermates (black, n = 5–10 per aged group) and Col6a1^GT/GT (red, n = 5–8 per aged group). (d) Grip power of male: control littermates (black, n = 7–11 per aged group) and Col6a1^GT/GT (red, n = 6–10 per aged group). (e) Voluntary wheel running (rotation per day) of control littermates (black, n = 28) and Col6a1^GT/GT (red, n = 28). Contractile properties of TA muscles of LM (black, n = 5 per aged group) and Col6a1^GT/GT (red, n = 5 per aged group); (f) peak isometric twitch, (g) maximal tetanic force, (h) cross-sectional area (CSA), (i) specific isometric twitch, (j) specific tetanic force, (k) twitch/tetanus ratio. Data represent the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 on the paired t-test were used. Numbers in graphs represent n for each data point.