Fig. 1.

Lyn regulated airway inflammation and ER stress in allergic airway inflammation disease. (a) Experimental design for the sensitization and challenge of WT mice and Lyn-TG mice with OVA. (b–d) Total cell numbers and cell differentials in the BALF were determined. (e–f) Representative H&E–stained sections of the lungs of WT mice and Lyn-TG mice (original magnification: 200 ×). The degree of peribronchial and perivascular inflammation was scored (Kruskal-Wallis test). (g) Representative immunohistochemical staining of BIP or CHOP in the lung tissue of WT mice and Lyn-TG mice. (h–i) Quantitation of the fluorescence intensity of BIP or CHOP per micrometer in 10 random fields. All data are presented as the mean ± s.d. (n = 8 each group, one-way ANOVA with Tukey-Kramer post-test.).