Figure 1.

Participant flow diagram. Timelines for data collection and follow-up are listed in the figure. *Reasons for ineligibility included meeting prespecified criteria including history of heart attack, angioplasty, heart surgery, chest pain, shortness of breath, fainting or angina within the past 3 months, brain aneurysm or cerebral hemorrhage within past 6 months, knee replacement or knee pain precluding testing, an abnormal electrocardiogram at baseline (Year 1), or markedly elevated blood pressure at the time of the study visit (systolic >199 mm Hg or diastolic >109 mm Hg).