Table 3. Hemodynamic measurements in 4-week bile duct-ligated rats after one-week treatment (values taken 2 h 30 min after the last dose of treatment).
| Dose (mg/kg/day) | n | MAP (mmHg) | PP (mmHg) | SMABF (mL/[min·100 g]) | SMAR (mmHg/mL·min·100 g) | Heart rate (bpm) | |
|---|---|---|---|---|---|---|---|
| Vehicle | 8 | 96.39 ± 6.84 | 18.53 ± 0.56 | 4.42 ± 0.31 | 17.99 ± 1.73 | 318.10 ± 12.88 | |
| Atorvastatin | 15 | 9 | 82.46 ± 4.44 | 16.27 ± 0.67* | 4.98 ± 0.41 | 13.95 ± 1.34 | 314.82 ± 9.96 |
| 10 | 11 | 84.11 ± 4.22 | 15.77 ± 0.59** | 3.63 ± 0.26 | 19.60 ± 1.59 | 314.65 ± 12.75 | |
| NCX 6560 | 35.1 | 9 | 105.83 ± 5.11 | 17.75 ± 0.64 | 4.30 ± 0.41 | 22.10 ± 2.43 | 327.77 ± 15.92 |
| 17.5 | 9 | 85.35 ± 5.95 | 16.25 ± 0.86* | 3.88 ± 0.37 | 19.24 ± 2.22 | 310.84 ± 13.40 | |
| 11.7 | 9 | 95.67 ± 6.42 | 16.43 ± 0.63* | 3.91 ± 0.41 | 22.17 ± 3.18 | 330.51 ± 9.05 |
Values are expressed as mean ± SEM. n, number of rats; MAP, mean arterial pressure; PP, portal pressure; SMABF, superior mesenteric artery blood flow; SMAR, superior mesenteric artery resistance. Equivalent doses: NCX 6560 17.5 mg/kg/day equals to atorvastatin 15 mg/kg/day and NCX 6560 11.7 mg/kg/day equals to atorvastatin 10 mg/kg/day. *p ≤ 0.05, **p ≤ 0.01 compared with vehicle.