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. 2017 Jan 13;7:40518. doi: 10.1038/srep40518

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Copyright © 2017, The Author(s)

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FTY720 was orally administered to Hexb^+/− or Hexb^−/− mice at 3–15 weeks of age. (A) Immunostaining of coronal sections for CD68 (green) and Iba1 (red) in the cerebral cortices of control and FTY720-treated Hexb^−/− mice at 15 weeks. Blue represents DAPI staining. Insets (a–d) show magnified views of the boxed regions. Scale bar, 100 μm. (B,C) Quantitative analysis of the number of CD68+ (B) and Iba1+ (C) cell immune signals in the cerebral cortices of control Hexb^+/−, FTY720-treated Hexb^+/−, control Hexb^−/−, and FTY720-treated Hexb^−/− mice at 15 weeks. Boxes, 25^th–75^th percentile with the median indicated; bars, 10^th and 90^th percentiles. Analyzed using a Kruskal–Wallis test (non-parametric ANOVA) followed by a Dunn’s post hoc test (n = 6). *P < 0.05.