Fig. 4.

Building an aggressiveness classifier. a Phylogenetic reconstruction showing clonal relationships in each patient based on all filtered HM450 probes. Averaged normal prostate and normal lymph node samples were used for each tree. Sample types are colored with black (normal and PIN), orange (aggressive primary tumor), green (non-aggressive primary tumor), yellow shaded (undecided primary tumor), and purple (lymph node metastasis). Below each tree the longest Euclidean distance between any two samples in the tree are denoted so as to serve as a reference between the different trees. b MDS plot based on a 25-probe classifier generated by GLMnet of the samples used for the analysis. The samples are separated into three distinct groups and show no overlap