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. 2017 Jan 5;14:3. doi: 10.1186/s12974-016-0780-7

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Involvement of EP2 in the expression of genes related to classical microglial activation. mRNA expression of iNOS (a, b), NOX2 (c, d), G6PD (e, f), and VEGFA (g, h) in microglia. a, c, e, g LPS increases mRNA expression at 24 h, and an EP2 antagonist (1 μM PF 04418948) reduces the effect of LPS (three to four independent experiments). b, d, f, h An EP2 agonist (1 μM butaprost) increases the mRNA expression of these genes at 8 h (three independent experiments). *p < 0.05, **p < 0.01, ***p < 0.001 vs. control; &p < 0.05 vs. LPS; ^# p = 0.06 vs. LPS. “EP2 antag” indicates EP2 antagonist