Table 2.
Analysis of variance of regional TSPO V T by diagnosis and TSPO genotype
| Factorial ANOVA | Independent t test | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Disease effecta | Genotype effecta | HC group | PD group | |||||||
| ROIs | F (df) | p | F (df) | p | HC-MAB (n = 11) |
HC-HAB (n = 11) |
%-difference | PD-MAB (n = 14) |
PD-HAB (n = 16) |
%-difference |
| Frontal | F (1,46) = 0.0 | 0.964 | F (1,46) = 24.5 | <0.001 | 13.9 (2.8) | 19.4 (2.8) | 33.0b | 11.8 (0.2) | 18.7 (1.6) | 45.2b |
| Temporal | F (1,47) = 0.0 | 0.846 | F (1,47) = 25.7 | <0.001 | 11.9 (2.9) | 16.1 (1.8) | 30.0b | 11.4 (1.2) | 16.6 (1.2) | 37.1b |
| Cingulate | F (1,35) = 0.6 | 0.427 | F (1,35) = 23.0 | <0.001 | 9.9 (1.6) | 12.3 (1.5) | 21.6 | 8.2 (0.0) | 13.7 (1.1) | 50.2b |
| Occipital | F (1,46) = 1.3 | 0.257 | F (1,46) = 21.8 | <0.001 | 12.3 (2.7) | 17.2 (2.4) | 33.2b | 13.6 (3.0) | 18.3 (1.4) | 29.5b |
| Insula | F (1,43) = 0.1 | 0.813 | F (1,43) = 34.6 | <0.001 | 10.6 (1.8) | 14.0 (1.6) | 27.6b | 9.8 (0.6) | 15.7 (1.3) | 46.3b |
| Hippocampus | F (1,34) = 0.1 | 0.720 | F (1,34) = 7.8 | 0.009 | 8.7 (1.9) | 10.4 (1.4) | 17.8 | 8.6 (2.4) | 12.4 (1.2) | 36.2b |
| Cerebellum | F (1,46) = 0.0 | 0.852 | F (1,46) = 34.4 | <0.001 | 9.6 (2.2) | 14.8 (1.6) | 42.6b | 9.2 (0.7) | 14.7 (1.3) | 46.0b |
| Thalamus | F (1,43) = 0.6 | 0.445 | F (1,43) = 15.8 | <0.001 | 12.8 (3.6) | 16.8 (2.6) | 27.0 | 13.5 (2.2) | 19.9 (2.0) | 38.3b |
| Caudate | F (1,32) = 0.0 | 0.927 | F (1,32) = 14.6 | 0.001 | 8.1 (1.8) | 12.4 (1.6) | 41.6b | 7.2 (0.3) | 12.9 (1.0) | 56.7b |
| Putamen | F (1,41) = 0.1 | 0.717 | F (1,41) = 25.9 | <0.001 | 8.0 (1.8) | 13.5 (1.3) | 51.2b | 7.8 (0.4) | 12.4 (1.1) | 45.5b |
Values are expressed as mean (SD). HAB, high affinity binders and MAB, mixed affinity binders refer to the single nucleotide polymorphism rs6971 of the TSPO gene known to influence [18F]-FEPPA binding. Percentage differences of the mean V T values between HC-HABs and HC-MABs as well as PD-MABs and PD-HABs
aMain effect of univariate ANOVA
bSignificantly different