Table 1.
Genomic characteristics of ALL specimens used for xenograft studies
| PDX | USI | Disease status | Ph-like ALL genomic lesions | ||
|---|---|---|---|---|---|
| CRLF2 | JAK | ABL class | |||
| NH362 | PALTWS | D | IGH@-CRLF2* | ||
| JH331 | PAMDKS | D | IGH@-CRLF2 | JAK2R683G | |
| JH612 | PAMDRM | D | IGH@-CRLF2 | JAK2GPinsR683 | |
| ALL121 | n/a | R | IGH@-CRLF2 | JAK2R683G | |
| ALL4364 | PAWAKV | R | P2RY8-CRLF2 | JAK2R683G | |
| JL491 | PAKMVD | D | JAK1S646F | ||
| NL482A | PAKYEP | D | BCR-JAK2 | ||
| NL432 | PAKKCA | D | EBF1-PDGFRB | ||
| NH011 | PAKVKK | D | NUP214-ABL1 | ||
| PHL3 | PANSFD | D | ETV6-ABL1 | ||
D, de novo; n/a, not available; R, relapse; USI, unique specimen identifier for primary patient sample.
*
Non–Ph-like by prediction analysis of microarrays.