Fig. 4.

WWL70 suppressed microsomal PGESs and COX-2 mRNA expression. qRT-PCR of mPGES-1 (a), mPGES-2 (b), or COX-2 (c) mRNA isolated from BV2 cells treated with WWL70 (10 μM) for 15 min, before addition of 2-AG (10 μM) for 15 min, and then LPS (0.1 μg/ml) for 18 h. Data are represented as relative expression to control condition after normalization with GAPDH (mean ± SD, n = 4). Single and double asterisks denote p < 0.05 and 0.01, respectively