Table 1.
Quality of the studies included according to Jadad scale
| Author | Type of study | Number of patients | Random sequence generation | Conceal-ment of allocation | Blinding | Jadad score | |
|---|---|---|---|---|---|---|---|
| Inter-vention | Control | ||||||
| Van Keimpema et al18 | RCT | 27 | 27 | Adequate | Adequate | Double blinded | 5/5 |
| Caroli A. et al19 | RCT | 12* | 12* | Adequate | Adequate | Double blinded | 5/5 |
| Hogan et al3 | RCT (2:1) | 28 | 14 | Not described | Not described | Double blinded | 3/5 |
| Chrispijn M. et al21 | Case series | 41 | 0 | Not applicable | Not applicable | Not applicable | 0/5 |
| Hogan et al20 | Case series | 41 | 0 | Not applicable | Not applicable | Not applicable | 1/5 |
| Chrispijn M. et al22 | RCT | 21 | 23 | Adequate | Adequate | Double blinded | 5/5 |
| Qian Q. et al23 | Case series | 7 | 9 | Not applicable | Not applicable | Not applicable | 0/5 |
*Cross over study, 6 patients in intervention and control groups crossed-over after 6 months, RCT: randomised controlled trial